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The next day, however, he reported feeling 'much better' as his bowel movements began to get 'more normal'.Ībout 16 people aged 18 to 45 years old were involved in the challenge trial at the University of Maryland.
'The antibiotics helped tremendously and my fever is gone, but I am still producing a French onion soup from hell every time I go to the bathroom.' 'I'm not totally recovered yet,' he wrote online. He also had a fever again, which soared up to 101F. The following day Mr Eberts said he began to feel 'much better' than beforehand, although continued to need the toilet regularly. Nurses decided to initiate treatment at this time, after he started showing symptoms of infection. 'I was so exhausted that I just laid down on the bathroom floor for several minutes.' 'I went to go to the bathroom and every single part of that - getting up, walking, grabbing toilet paper - felt like a Herculean effort,' he wrote. He had visited the toilet 11 times that day and was also feeling extremely tired. Over that day, Mr Eberts said he had started suffering dysentery and soiled himself twice. 'No diarrhea yet, but Chekhov's diarrhea revolver is now just hanging above me and every time I I am pulling the trigger in the world's worst game of Russian roulette.' Cramps, slight chills, stool sample normal, at least visually. Mr Eberts was one of 16 people in the phase two challenge trial testing one - which has the scientific name SF2a-TT15.Īfter drinking the shigella, he reported on Twitter feeling well over the first two days after being infected.īut on day three he wrote at 2.50am: 'Woken up by what I can only describe as a feeling of funny business in my gut. There is currently no vaccine available against shigella, although several candidates are in development. I cannot imagine how terrifying this disease is for a small child.' Summing up the illness, Mr Eberts said: 'That was the most brutally sick I have ever been, and I wanted to die for a solid six hours. He suspects he got the placebo, or inactive vaccine, because the sickness was so bad. He had received two jabs about a month apart, and was incarcerated for 11 days until the infection cleared.
Mr Eberts was infected in a challenge trial, where participants get an experimental jab or placebo and before being exposed to the disease they were inoculated against. Nurses were quick to give him fluids to replace what was being lost, and put him on antibiotics to help fight the infection. Over the next 48 hours he faced stomach cramps, bloody diarrhea, a fever of 103F, and felt so exhausted that lifting any of his limbs was a 'Herculean effort'. Within three days he was waking up early with a feeling of 'funny business' in his stomach and having to rush to the bathroom. Jake Eberts, from Washington D.C., was paid $7,000 to ingest the shigella bacteria - often spread by contaminated water - at Maryland University last month. A 26-year-old researcher who drunk a shot of dysentery-triggering bacteria for a vaccine trial was left rushing for the toilet and feeling so ill he 'wanted to die'.